Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers
نویسندگان
چکیده
منابع مشابه
Leukotriene BLT2 receptor monomers activate the G(i2) GTP-binding protein more efficiently than dimers.
Accumulating evidence indicates that G protein-coupled receptors can assemble as dimers/oligomers but the role of this phenomenon in G protein coupling and signaling is not yet clear. We have used the purified leukotriene B(4) receptor BLT2 as a model to investigate the capacity of receptor monomers and dimers to activate the adenylyl cyclase inhibitory G(i2) protein. For this, we overexpressed...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2019
ISSN: 2198-3844,2198-3844
DOI: 10.1002/advs.201900143